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Epi Canary — Epidemic IntelligenceEvidence-led epidemic intelligence. Source-attributed evidence.
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Public note

For situational awareness and research transparency. Not medical advice.

Novel Pathogen Detectionactive

At least 5 additional novel NDM (New Delhi metallo-β-lactamase) variants (NDM-64 through NDM-68 or beyond — building on the ~100 variants reported through NDM-63, the L3-loop variant in Klebsiella pneumoniae described in PMC12888852) will be deposited in NCBI Pathogen Detection / Beta-Lactamase Database / GenBank between 2026-04-20 and 2027-04-20.

System-generated assessment. This assessment remains under review until the stated horizon or until sufficient evidence allows evaluation.

Substantial confidence

Confidence in this assessment
60%

Multiple lines of evidence are aligned, though the assessment remains provisional. Based on 4 linked evidence items and assessed against 365D.

Assessed through 365D·4 linked evidence items·Tracking since Apr 20, 2026

02

How this assessment will be evaluated

The criteria the system uses to determine whether this assessment is borne out by the stated horizon.

Automated

Method

Evidence Match

The condition the system checks for when evaluating this assessment.

Minimum source quality

T1Primary Institutional

Evidence must meet or exceed this credibility tier to count toward evaluation.

Required terms

beta-lactamasepmc12888852additional-lactamase

03

Evidence quality mix

Tracking since Apr 20, 2026.

T24
▸Integrity referencesCryptographic hashes for verification

Registration

06

Scope synthesis

The current analyst narrative for this scope.

Open synthesis →

AMR evidence pipeline severely constrained this cycle; two hypotheses resolve Apr 27 without confirmatory data; PubMed failure and stale secondary connectors limit incident coverage.

07

Evidence linked to this assessment

4 linked items.

SURVEILLANCE (113): OMAN, ESCHERICHIA COLI, EXTENDED-SPECTRUM BETA-LACTAMASE, ANTIMICROBIAL RESI

Currently interpreted as supporting evidence for 1 tracked assessment.

T2https://www.promedmail.org/?alert=8732337supports
Apr 20, 2026
SURVEILLANCE (113): OMAN, ESCHERICHIA COLI, EXTENDED-SPECTRUM BETA-LACTAMASE, ANTIMICROBIAL RESI

Currently interpreted as supporting evidence for 1 tracked assessment.

T2https://www.promedmail.org/?alert=8732337supports
Apr 20, 2026
SURVEILLANCE (113): OMAN, ESCHERICHIA COLI, EXTENDED-SPECTRUM BETA-LACTAMASE, ANTIMICROBIAL RESI

Currently interpreted as supporting evidence for 1 tracked assessment.

T2https://www.promedmail.org/?alert=8732337supports
Apr 20, 2026
SURVEILLANCE (113): OMAN, ESCHERICHIA COLI, EXTENDED-SPECTRUM BETA-LACTAMASE, ANTIMICROBIAL RESI

Currently interpreted as supporting evidence for 1 tracked assessment.

T2https://www.promedmail.org/?alert=8732337supports
Apr 20, 2026
Mirror replication is delayed on 1 of 3 tables. Showing last replicated data.

Integrity anchor

Brier 0.202

19 resolved novel pathogen detection predictions.