Association between COVID-19 status and Leydig cell functional capacity among men in hospitalized cohorts.

T2Wire / Structuredvia pubmedRetrieved Apr 17, 2026View original source ↗

Grounds assessments

activeBA.3.2 ("Cicada") will cause a detectable wastewater elevation (≥20% increase from Q1 2026 baseline) in ≥3 of the 14 monitored countries by 2026-06-30, driven by immune escape from prior SARS-CoV-2 immunity.50%resolvedSARS-CoV-2 wastewater concentrations across 14 monitored countries will remain below winter 2025-26 peak through Q2 2026.90%

Evidence content

The first wave of the COVID-19 pandemic in the UK in 2020 led to significant morbidity, hospitalization, and death, particularly amongst elderly men. Recent meta-analyses confirmed that SARS-CoV-2 infection led to reduced testosterone and increased LH, suggestive of testicular Leydig cell involvement. The unique Leydig cell biomarker insulin-like peptide 3 (INSL3) was measured in two cohorts of hospitalized men in Nottingham and London with moderate to severe COVID-19 symptoms. For Nottingham men, circulating INSL3 was reduced at entry (0.36 0.34 ng/ml; n...

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Run ID: 244e5d22-f1c9-45d9-b406-41cbef1a8633
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