The effectiveness of COVID-19 vaccines and the added benefit of booster doses in Hessen, Germany, during the COVID-19 pandemic: Results from a vaccinated-only study.

T2Wire / Structuredvia pubmedRetrieved Apr 17, 2026View original source ↗

Grounds assessments

activeBA.3.2 ("Cicada") will cause a detectable wastewater elevation (≥20% increase from Q1 2026 baseline) in ≥3 of the 14 monitored countries by 2026-06-30, driven by immune escape from prior SARS-CoV-2 immunity.50%resolvedSARS-CoV-2 wastewater concentrations across 14 monitored countries will remain below winter 2025-26 peak through Q2 2026.90%

Evidence content

Estimates of the added benefit from COVID-19 vaccine booster doses can inform seasonal vaccine recommendations. We set out to estimate COVID-19 vaccine effectiveness (VE), avoiding common sources of bias. We chose a modified screening method, using only vaccinated cases of symptomatic COVID-19 recorded in the mandatory infectious disease reporting system, with data from a vaccination registry. Effect estimates were obtained by Bayesian logistic regression, comparing outcomes within dose strata between immunized (15-21d after vaccination) and not yet immunized (up to...

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