Genomic diversity of Clade Ia monkeypox virus in the Central African Republic, 2019-2024.

T2Wire / Structuredvia pubmedRetrieved Apr 17, 2026View original source ↗

Grounds assessments

activeA locally-acquired Clade I mpox transmission chain (≥2 epidemiologically linked cases without African travel history) will be confirmed in North America within 90 days of the San Francisco Clade I detection (Apr 19 2026).40%resolvedMpox clade Ib will be confirmed in at least 2 East African countries outside the DRC by April 2026.90%resolvedMpox Clade Ib will establish at least one additional documented sustained community transmission chain outside the African continent by July 2026.70%

Evidence content

Monkeypox virus (MPXV) is a zoonotic pathogen known to be endemic to the Congo basin and West Africa, and which causes characteristic lesions disseminated on all skin surfaces of infected cases. Multiple MPXV outbreaks have been reported in the Central African Republic (CAR), a country in the Congo basin, at an increased frequency since 2020. The genomic history of these outbreaks in CAR is poorly characterized due to undersampling, with only a recent expansion in the number of sequences from...

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