Monkeypox virus replication and host response in vaginal and ectocervical epithelial cells.

T2Wire / Structuredvia pubmedRetrieved Apr 17, 2026View original source ↗

Grounds assessments

activeMpox Clade IIb C.1 community transmission in Phnom Penh will be documented to involve a heterosexual or mixed-route transmission cluster by July 2026, based on phylogenomic confirmation of community spread and newly published MPXV replication efficiency in vaginal and ectocervical epithelial tissue.50%activeFemale sex worker involvement will be documented in the Phnom Penh Clade IIb C.1 outbreak by September 2026, consistent with MPXV replication efficiency in vaginal and ectocervical tissue and the mixed-network structure of sex worker outreach programs in Cambodia.50%

Evidence content

Recent mpox outbreaks have shown a predominant transmission through sexual contact. Replication-competent virus has been detected in seminal fluid, while in female patients, vaginal lesions, vertical transmission, and miscarriage risk have been reported. This study explored the susceptibility of the lower female genital tract (LFGT) to monkeypox virus (MPXV) infection, the role of sex-hormones in modulating viral replication, and host-virus molecular interactions. Human vaginal (VK2/E6E7) and ectocervical (Ect1/E6E7) epithelial cells were exposed to MPXV clade IIb, and viral replication was...

Technical metadataPipeline attribution for verification

Connector: pubmed
Payload kind: article
Run ID: 3c400bb4-8e73-4276-9284-ac517d778eb4
Schema version: —

Assessment unavailable

This assessment could not be loaded right now because no recent cached snapshot is available.