Maternal Chikungunya virus infection and pregnancy outcomes: a global systematic review and meta-analysis of vertical transmission dynamics and associated morbidity.

T2Wire / Structuredvia pubmedRetrieved Apr 22, 2026View original source ↗

Grounds assessments

activeLa Réunion 2026 chikungunya outbreak will exceed 100,000 cumulative confirmed/suspected cases by September 2026 (from approximately 47,000 as of Apr 22 2026), one of the largest CHIK events in Indian Ocean island history.60%activeAutochthonous chikungunya transmission will be documented in at least one additional Chinese province beyond Guangdong during the 2026 warm season (May–October), confirmed by national health authority or peer-reviewed publication.50%activeLa Réunion 2026 chikungunya outbreak will exceed 100,000 cumulative reported cases by August 31 2026, based on the 47,500+ case trajectory as of April 2026 and the historical precedent of the 2005-2006 Réunion epidemic reaching 266,000 cases over a longer surveillance period, given that 2026 surveillance capacity and reporting speed are substantially higher than 2005.60%activeECDC will issue a rapid risk assessment or seasonal preparedness alert specifically addressing La Réunion and/or Mayotte chikungunya importation risk for Mediterranean Europe (Italy, Spain, France, Greece) before the 2026 vector season peak (by July 1, 2026), given the 47,500+ case scale of the La Réunion outbreak and established Aedes albopictus populations in Southern Europe.50%resolvedLa Réunion chikungunya outbreak will sustain >10,000 cumulative reported cases through at least July 31 2026, maintaining active seeding pressure on metropolitan France during the peak Aedes albopictus transmission window.70%activeViremic travelers from La Réunion will seed at least one documented autochthonous chikungunya cluster (≥2 locally-acquired cases) in Italy, Spain, or Greece during the 2026 vector season (July–October), given the scale of the current La Réunion outbreak (47,500+ cases) and established Aedes albopictus populations in Mediterranean Europe.50%activeFirst confirmed autochthonous dengue or chikungunya transmission in the UK, Netherlands, Belgium, or Germany will be documented during the 2026 or 2027 Northern Hemisphere transmission season (June–October).30%

Evidence content

Chikungunya virus (CHIKV) infection during pregnancy presents a major threat to maternal-fetal health, yet a comprehensive global assessment of vertical transmission risks and perinatal outcomes remains scarce. To provide a comprehensive evidence synthesis, we conducted a systematic review and meta-analysis, prospectively registered in PROSPERO (CRD420251164423). We screened studies published up to October 20, 2025, and included 57 observational studies for qualitative synthesis, with 27 studies pooled in meta-analyses. The pooled vertical transmission rate was 18.1%, revealing a pronounced gestational-age gradient:...

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