Modulating Chikungunya and Mayaro virus-induced disease severity in mice using low concentrations of anti-IFNAR1 antibodies.

T2Wire / Structuredvia pubmedRetrieved Apr 17, 2026View original source ↗

Grounds assessments

activeLa Réunion 2026 chikungunya outbreak will exceed 100,000 cumulative confirmed/suspected cases by September 2026 (from approximately 47,000 as of Apr 22 2026), one of the largest CHIK events in Indian Ocean island history.60%activeAutochthonous chikungunya transmission will be documented in at least one additional Chinese province beyond Guangdong during the 2026 warm season (May–October), confirmed by national health authority or peer-reviewed publication.50%activeLa Réunion 2026 chikungunya outbreak will exceed 100,000 cumulative reported cases by August 31 2026, based on the 47,500+ case trajectory as of April 2026 and the historical precedent of the 2005-2006 Réunion epidemic reaching 266,000 cases over a longer surveillance period, given that 2026 surveillance capacity and reporting speed are substantially higher than 2005.60%activeECDC will issue a rapid risk assessment or seasonal preparedness alert specifically addressing La Réunion and/or Mayotte chikungunya importation risk for Mediterranean Europe (Italy, Spain, France, Greece) before the 2026 vector season peak (by July 1, 2026), given the 47,500+ case scale of the La Réunion outbreak and established Aedes albopictus populations in Southern Europe.50%resolvedLa Réunion chikungunya outbreak will sustain >10,000 cumulative reported cases through at least July 31 2026, maintaining active seeding pressure on metropolitan France during the peak Aedes albopictus transmission window.70%activeViremic travelers from La Réunion will seed at least one documented autochthonous chikungunya cluster (≥2 locally-acquired cases) in Italy, Spain, or Greece during the 2026 vector season (July–October), given the scale of the current La Réunion outbreak (47,500+ cases) and established Aedes albopictus populations in Mediterranean Europe.50%activeFirst confirmed autochthonous dengue or chikungunya transmission in the UK, Netherlands, Belgium, or Germany will be documented during the 2026 or 2027 Northern Hemisphere transmission season (June–October).30%

Evidence content

The laboratory mouse ( Mus musculus ) is the most widely used animal model for preclinical research, with numerous wild-type and genetically modified mouse strains available. Chikungunya virus (CHIKV), a mosquito-borne arthritogenic alphavirus, has emerged in various new regions and caused several millions of cases within the last decade. Mayaro virus (MAYV), an arthritogenic alphaviruses closely related to CHIKV, remains geographically restricted to the Americas. Existing mouse models rely on immunodeficient mice, leading to lethal illness, or footpad injection, which...

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