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Epi Canary — Epidemic IntelligenceEvidence-led epidemic intelligence. Source-attributed evidence.
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Public note

For situational awareness and research transparency. Not medical advice.

Novel Pathogen Detectionactive

California will confirm at least 2 additional Clade I mpox cases (beyond the San Francisco Apr 16 index) within 60 days of Apr 20 2026, with at least one in Los Angeles County or adjacent counties — indicating multi-focus Clade I circulation rather than isolated importation.

System-generated assessment. This assessment remains under review until the stated horizon or until sufficient evidence allows evaluation.

Substantial confidence

Confidence in this assessment
60%

Multiple lines of evidence are aligned, though the assessment remains provisional. Based on 6 linked evidence items and assessed against 60D.

Assessed through 60D·6 linked evidence items·Tracking since Apr 20, 2026

02

How this assessment will be evaluated

The criteria the system uses to determine whether this assessment is borne out by the stated horizon.

Automated

Method

Evidence Match

The condition the system checks for when evaluating this assessment.

Minimum source quality

T1Primary Institutional

Evidence must meet or exceed this credibility tier to count toward evaluation.

Required terms

multi-focuscirculationimportationcalifornia

03

Evidence quality mix

Tracking since Apr 20, 2026.

T25
T31
▸Integrity referencesCryptographic hashes for verification

Registration

06

Scope synthesis

The current analyst narrative for this scope.

Open synthesis →

Clade Ib multi-modal European spread continues; new research confirms MPXV replication in vaginal/ectocervical tissue, strengthening plausibility of non-sexual transmission routes.

07

Evidence linked to this assessment

6 linked items.

MPOX - USA (03): (CALIFORNIA) SAN FRANCISCO, CLADE I. The CDPH is monitoring the situation and e

Currently interpreted as supporting evidence for 2 tracked assessments.

T2https://www.promedmail.org/?alert=8732325supports
Apr 19, 2026
MPOX - USA (03): (CALIFORNIA) SAN FRANCISCO, CLADE I. The California Department of Public Health

Currently interpreted as supporting evidence for 2 tracked assessments.

T2https://www.promedmail.org/?alert=8732325supports
Apr 19, 2026
California Clade I Mpox — signal expansion Apr 17-19 2026 (Google News RSS aggregation). Multi-o

Currently interpreted as supporting evidence for 2 tracked assessments.

T3https://news.google.com/rss/search?q=mpox%20cases%20in%20Californiasupports
Apr 20, 2026
9 Mpox deaths, 25 cases reported across Sindh province, Pakistan. Dunya News, April 15 2026. The

Currently interpreted as supporting evidence for 11 tracked assessments.

T2https://dunyanews.tv/en/Pakistan/mpox-sindh-deaths-casessupports
Apr 16, 2026
MPOX - GHANA (05): EPIDEMIC UPDATE. The Ghana Health Service has confirmed additional cases of m

Currently interpreted as supporting evidence for 12 tracked assessments.

T2https://www.promedmail.org/?alert=8732298supports
Apr 17, 2026
Pakistan Sindh Mpox Update — Apr 14 2026 (Sindh Health Department, via The Nation Pakistan, Apr

This report is recorded in the evidence trail but is not yet linked to a tracked assessment.

T2https://www.nation.com.pk/16-Apr-2026/mpox-update-25-confirmed-cases-9-deaths-reported-sindhneutral
Apr 20, 2026

Integrity anchor

Brier 0.202

19 resolved novel pathogen detection predictions.