Shigellosis: USA, increasing incidence, antimicrobial resistance, 2023

T2Wire / Structuredvia promedRetrieved Apr 20, 2026View original source ↗

Grounds assessments

activeECDC will formally classify Candidozyma auris (formerly Candida auris) as endemic in ≥3 EU/EEA countries via a technical report, surveillance update, or risk assessment by 2026-10-17, formalizing the trajectory described in Medscape 2026-04-13 ("C auris Is Now Endemic in Europe. Can It Be Contained?") and CIDRAP 2025-09-11 ("Multidrug-resistant yeast cases rising rapidly in Europe, survey shows").60%activetetM-carrying N. gonorrhoeae prevalence in US surveillance reaches ≥30% by EOY 2026 OR ≥3 independent confirmed extensively drug-resistant (ceftriaxone+azithromycin+ciprofloxacin simultaneously resistant) N. gonorrhoeae transmission clusters documented in US/EU/AU during 2026, threatening the doxyPEP era and last-line cephalosporin therapy.60%activeCDC will publish a Morbidity and Mortality Weekly Report (MMWR) early release or health advisory specifically characterizing XDR Shigella (azithromycin + fluoroquinolone + 3GC resistant) geographic spread and treatment guidance within 60 days of the April 13 2026 emergence report (by June 12 2026), consistent with CDC's precedent of issuing MMWR early releases for novel drug-resistant Shigella phenotypes (2022-2023 ceftriaxone-resistant Shigella MMWR).60%expiredAt least one XDR Shigella case with genomic linkage to the US April 2026 emergence cluster will be confirmed in Australia, Canada, or Japan within 120 days (by August 13 2026), based on high-frequency MSM travel networks connecting these countries to the US, and the historical 2022-2023 pattern where drug-resistant Shigella reached high-income Pacific Rim countries within 8 months of initial US detection.40%expiredXDR Shigella (extensively drug-resistant, resistant to azithromycin + fluoroquinolones + 3GC) will establish sustained community transmission in at least 3 US states within 12 months of CDC's April 2026 emergence report, requiring updated CDC treatment guidance and triggering enhanced surveillance protocols.40%activeAt least one additional case of XDR Shigella sonnei carrying BOTH blaDHA-1 (cephalosporinase) and blaCTX-M-15 (ESBL) — the dual-cephalosporinase phenotype first reported in two epidemiologically unlinked LA patients (Yang et al., Antimicrobial Stewardship & Healthcare Epidemiology, CIDRAP 2026-01-14) — will be reported in any T1 source (CDC, MMWR, peer-reviewed journal, ECDC, GLASS) by 2026-07-21.60%

Evidence content

The CDC has issued an alert regarding a growing public health threat: a drug-resistant form of the bacteria Shigella, which causes shigellosis. This resistant strain is spreading within the United States and does not respond to common antibiotics. The infection spreads easily and can cause severe symptoms, with some individuals experiencing prolonged illness or serious complications. The CDC is monitoring the outbreak and recommends preventative measures such as handwashing and avoiding contaminated food. They also advise doctors to report cases and follow new guidelines. Diseases: Shigellosis, Antimicrobial resistance. Places: United States. Species: Humans.

Technical metadataPipeline attribution for verification

Connector: promed
Payload kind: alert
Run ID: a2488a29-cc72-4e51-9ed4-df91a11f3698
Schema version: —

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